Целью настоящего исследования была оценка особенностей влияния мономера метилметакрилата на морфологию слизистой оболочки полости рта крыс. Морфометрически обосновано, что мономер метилметакрилат оказывает повреждающее действие на слизистую оболочку полости рта экспериментальных животных в виде умеренно выраженных воспалительно-дистрофических явлений. Установлено, что применение геля для полости рта «Профиал» в условиях эксперимента снижает интенсивность раздражающего действия метилметакрилата и оказывает выраженный противовоспалительный профилактический эффект.
made of natural or artificial high molecular compounds (HMC), which are able under the action of heating and pressure to keep their original shape. There were 30 rats under the research, devided into 3 groups. The 1st
group consisted of intact animals under the standard conditions of vivarium. The animals of the 2nd group were under the action 1% solution of monomer (methyl ether of metacril acid) as applications of 2.2 mm cotton wool tampon on the mucous membrane in the area of transitional fold and adjoining cheek and gum during 2–3 sec. The 3rd group were animals which were applied “Profial” gel at a background of methylmethacrylate applications.
Results. The researches showed that intact rats have pronounced two-layer structure of mucous membrane. Outside it is covered by keratinizing epithelium, in which some layers of cells are visible. The area of the corneal layer approximately 2 times exceeds the area of cellular layers. The monomer of methylmethacrylate renders the damaging action on the oral mucosa of experimental animals as moderately pronounced inflammatory-dystrophic phenomena. The usage of “Profial” gel lowers intensity of irritating action of methylmethacrylate and renders
pronounced antiinflammatory prophylactic effect.
